A 70-something with Ventricular Paced Rhythm and Chest Pain
I was shown this ECG and asked for my opinion:
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What do you think? |
I did not know there was a previous to compare with (see below).
I said: “There is a ventricular paced rhythm (VPR). There is 1 mm of concordant ST Elevation in lead V5 All other leads have appropriate discordance, whether discordant ST elevation or depression. When there is just a single lead that meets the Smith modified Sgarbossa criteria, then the full criteria are met. Our PERFECT study had 96% specificity of this finding for Occlusive MI (OMI).”
One question posed: “Isn’t this discordant STE? There is an S-wave prior to the ST segment” Answer: “We use the majority of the QRS.”
“However, among all patients who come to the ED with chest pain (whether with LBBB, paced rhythm, or normal conduction), only about 2% have an acute coronary occlusion. So the low pretest probability results in a much lower positive predictive value (PPV) than one might think.”
The PPV for sens = 81%, spec = 96% and prior probability of OMI = 2% is 29.2%.
The NPV for sens = 81%, spec = 96% and prior probability of OMI = 2% is 99.6%.
I recommended cath lab activation even though the PPV is only ~30%.
Then I was told that his first troponin I was 6.0 ng/mL. This result elevates the PPV to near 100%.
How did we already know the troponin? It turns out that the patient had presented almost 2 hours prior. After return of the troponin at 6 ng/mL, a 2nd ECG was recorded and was identical.
I am not certain if the findings on the first ECG (before troponin result) were not seen or not believed, but this would be typical: OMI in paced rhythm is frequently missed.
It is believed by many that OMI cannot be diagnosed in the presence of VPR. And therefore patients with VPR are denied reperfusion therapy routinely. Rathore et al. showed that these patients are extremely undertreated.
The cath lab was activated.
The cardiologist came down to the ED. He performed a bedside echo which confirmed an apical wall motion abnormality.
He also found a previous ECG. Here it is:
The angiogram did indeed show mid-LAD occlusion of a wraparound LAD. It was stented.
Post PCI, the troponin rose to 78 ng/mL.
The formal echo showed:
Learning Points
1. New or increased ST Elevation compared to previous VPR ECG is very specific for OMI.
2. Even without the previous ECG, the Smith Modified Sgarbossa Criteria have very high sensitivity, specificity, and accuracy for OMI in VPR.
Criteria are:
1. Any single lead with 1 mm concordant ST Elevation
2. Any of leads V1-V3 with 1 mm of concordant ST depression.
3. Any single lead with excessively discordant ST elevation as defined by 25% of preceding S-wave.
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